FGF-5 analogous protein, and pharmaceutical composition containi

Details FGF-5 analogous protein, and pharmaceutical composition containi FGF-5 analogous protein, and pharmaceutical composition containi

1997-03-19

1999-02-23

Kemmerer, Elizabeth

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

514 12, 530399, A61K 3818, C07K 1450, C12N 1516

Patent

active

058742549

ABSTRACT:
The present invention relates to a novel FGF-5 analogous protein derived from mature mRNA formed by directly binding exon 1 to exon 3 in the splicing of a gene coding for FGF-5 protein as well as to a pharmaceutical composition containing the same as an active ingredient. The pharmaceutical composition containing the novel FGF-5 analogous protein of the present invention as an active ingredient can regulate physiological functions of FGF-5, such as regulation of restoration or development of hairs on the head and body, regulation of trophic and functional regulation in the brain and nervous system, proliferation of fibroblasts, etc.

REFERENCES:
"The rate FGF-5 mRNA variant generated by alternative splicing encodes a novel truncated from of FGF-5" by Hattori et al.; Biochimica et Biophysica Acta 1306 (1996) pp. 31-33.
"The Human FGF-5 Oncogene Encodes a Novel Protein Related to Fibroblast Growth Factors" by Zhan et al.; Molecular and Cellular Biology, Aug. 1988, pp. 3487-3495.
"Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system" by Haub et al.; Proc. Natl. Acad. Sci. USA, vol. 87, pp. 8022-8026, Oct. 1990, Neurobiology.

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