Fetal polypeptides from human liver

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C530S333000, C435S004000

Reexamination Certificate

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11182592

ABSTRACT:
Novel fetal genes (fls353 and fls485) have been successfully isolated from human fetal liver-derived cDNAs. These genes were specifically expressed in tissues including fetal tissues which are thought to contain a large number of undifferentiated cells and actively differentiating/proliferating cells. High levels of expression of these genes were observed also in a variety of cancer cells. The proteins and genes encoding the proteins can be used as the tool for developing drugs for the treatment of tumors.

REFERENCES:
patent: 2002/0115599 (2002-08-01), Vernos et al.
patent: 0736543 (1996-10-01), None
patent: WO 99/04265 (1999-01-01), None
patent: WO 99/37788 (1999-07-01), None
patent: WO 00/60071 (2000-10-01), None
patent: WO 01/57058 (2001-08-01), None
Heidebrecht et al. (1997) Blood, vol. 90, pp. 226-233.
NCBI report of NP—036244 with gi: 20127519 (orginally created in Oct. 26, 2000).
Ambrosini, G., et al. (1997). A novel anti-apoptosis gene,survivin, expressed in cancer and lymphoma. Nat Med. 3(8):917-921.
Bischoff, J.R., et al. (1998). A homologue ofdrosophila aurorakinase is oncogenic and amplified in human colorectal cancers. EMBO J. 17(11):3052-3065.
Frahm, S.O., et al. (1999). Immunoenzymatic detection of the new proliferation associated protein p100 by means of a cellular ELISA: specific detection of cells in cell cycle phases S, G2 and M. J Immunol Methods. 223(2):147-153.
Hufton, S.E., et al. (1999). A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization. FEBS Lett. 463(1-2):77-82.
Manda, R., et al. (1999). Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. Genomics. 61(1):5-14.
Nezu, J. Fetal gene preferentially expressed in colorectal cancer. Database Embl Online!, Database accession No. AB024704, Apr. 20, 1999.
Su, L., et al. (1993). LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation. Genes Dev. 7(5):735-748.
Tamai, I., et al. (1997). Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett. 419(1):107-111.
Wittmann, T., et al. (2000). TPX2, A novelxenopusMAP involved in spindle pole organization. J Cell Biol. 149(7):1405-1418.
Zhang, Y., et al. (1999). Assignment of human proliferation associated p100 gene (C20orf1) to human chromosome band 20q11.2 byin situhybridization. Cytogenet Cell Genet. 84(3-4):182-183.
Geneseq Accession No. AAX40161, available Jul. 2, 1999.

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