Fetal fibronectin pregnancy test

Details Fetal fibronectin pregnancy test Fetal fibronectin pregnancy test

1988-12-12

1993-02-09

Rosen, Sam

Chemistry: analytical and immunological testing

Immunochemical pregnancy determination

435709, 436518, 436 65, 436814, 436 86, G01N 3353, G01N 3348

Patent

active

051852705

ABSTRACT:
A method for determining normal intrauterine pregnancy during the first 20 weeks of pregnancy comprises obtaining a test sample; and determining the presence of a fetal restricted antigen in the sample. The test sample is removed the vaginal cavity in the vicinity of the cervical canal and/or the cervical os. One fetal restricted antigen is fetal fibronectin.
In one embodiment of this invention, the test sample is contacted with an insoluble support to which anti-(fetal restricted antigen) antibody is adhered, and the fetal restricted antigen binding to the support is determined. Alternatively, the test sample is contacted with an insoluble support to which is adhered an antibody which binds a class of substances including the fetal restricted antigen; and the fetal restricted antigen binding to the support is determined. Reagents and reagent kits are also included.

REFERENCES:
patent: 4279992 (1981-07-01), Boguslaski et al.
patent: 4325867 (1982-04-01), Eberle et al.
patent: 4675286 (1987-06-01), Calenoff
H. Gray, Gray's Anatomy, Bounty: New York, pp. 1025-1031 (1977).
Int. J. Cancer: 27, 763-767 (1981) "Fibronectin From Human Germ-Cell Tumors Resembles Amniotic Fluid Fibronectin" by Ruoslahti, et al.
Wisdom, G. B., Clinical Chemistry, vol. 22(8), pp. 1243-1255 (1976).
Oellerich, M., J. Clin. Chem. Clin. Biochem., vol. 22(12), pp. 895-904 (1984).
Atherton, B. et al, Cell 25:133-141 (1981).
Barnea, E. et al, ".beta.-HCG and Other Chemical Parameters of Ectopic Pregnancy". Maryland: Aspen Publishers, Inc. (1986).
Batzer, F., Contemporary Ob/Gyn 7-16 (1987).
Bell, S., Human Reproduction 1:129-143 (1986).
The Human Placenta, Boyd, J. et al. New York: MacMillan Press (1970).
Bray, B. Biochem. J. 226:811-815 (1985).
Bulmer, J. et al, Placenta 6:127-140 (1985).
Butzow, R. et al, Human Reproduction 1:287-289 (1986).
Chiquet-Ehrismann, R. et al, Cell 47:131-139 (1986).
Cossu, G. et al, J. Biol. Chem. 258:5603-5607 (1983).
Cruz, R. et al, J. Clin. Endocrinol. Metab. 64:433-440 (1987).
Davis, F. et al, Proc. Natl. Acad. Sci. USA 80:2926-2930 (1983).
Fletcher, J. Primary Care 13:667-677 (1986).
Fritz, M. et al, Fertility and Sterility 47:584-589 (1987).
Ganrot, P., Scand. J. Clin. Lab. Invest. 29:83-88 (1972).
Gelletlie, R. et al, Clin. Chem. 32:2166-2170 (1986).
Hayashi, M. et al, J. Biol. Chem. 256:11292-11300 (1981).
Hess, L. et al, Obstet. Gynecol. 68:25-28 (1986).
Immunoassays for the 80s, Voller et al (ed.). Baltimore: University Park Press (1981).
Johnson, P. et al, The Journal of Immunology 132:1608-1610 (1984).
Kiyotoshi, S. et al, Biochem. Biophys. Res. Comm. 116:534-540 (1983).
Kuusela, P. et al, Scand. J. Immunol. 12:331-337 (1980).
Liu, M. et al, Proc. Natl. Acad. Sci. USA 82:34-37 (1985).
Matsuura, H. et al, Proc. Natl. Acad. Sci. USA 82:6517-6521 (1985).
McCoshen, J. Contemporary Ob/Gyn May, 1987:94-117.
McSweeney, D. et al, Fertility and Sterility 18:866-869 (1967).
Nakabayashi, H. et al, Cancer Res. 42:3858-3863 (1982).
Pregnancy Proteins: Biology, Chemistry and Clinical Application, Grudzinskas, J. et al (ed.). New York: Academic Press (1982).
Ruoslahti, E. et al, Int. J. Cancer 27:763-767 (1981).
Sandler, S. et al, S. A. Medical Journal (Sep. 1977): 487-492.
Sekiguchi, K. et al, J. Biol. Chem. 258:3967-3973 (1983).
Sekiguchi, K. et al, J. Biol. Chem. 260:5105-5114 (1985).
Sinosich, M. et al, Obstet. and Gynecol. Survey 40:273-282 (1985).
Stern, P. et al, J. Immunol. 137:1604-1609 (1986).
Ulloa-Aguirre, A. et al, J. Clin. Endocrin. Metab. 64:1002-1009 (1987).
Van Kooij, R. et al, Fertility and Sterility 34:226-233 (1980).
Vuento, M. et al, Hoppe-Seyler's Z. Physiol. Chem. 361:1453-1456 (1980).
Wagner, D. et al, J. Biol. Chem. 256:11708-11715 (1981).
Yeh, H. et al, Radiology 161:463-467 (1986).
Yuen, H., "Clinical Applications of the HCG-.beta. Subunit Assay in Obstetrics and Gynecology", Current Problems in Obstetrics, Gynecology and Fertility. Chicago: Year Book Medical Publishers, Inc. (Sep. 1985).
Zardi, L. et al, Int. J. Cancer 25:325-329 (1980).
Zhu, B. et al, J. Biol. Chem. 259:3962-3970 (1984).

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