Fertility prediction by use of clomiphene challenge test

Details Fertility prediction by use of clomiphene challenge test Fertility prediction by use of clomiphene challenge test

1989-04-06

1992-02-25

Rosen, Sam

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

436 65, 436811, 436906, A61K 4900

Patent

active

050911708

ABSTRACT:
The fertility of females, especially human females can be predicted by use of a clomiphene challenge test. The test is based upon comparison of follicle stimulating hormone and/or luteinizing hormone levels in urine or blood samples at two points in the menstrual cycle. The first test is performed on days 2-3 of the cycle. Clomiphene, and most preferably clomiphene in the form of clomiphene citrate, in a dosage of about 100 mg/day, is then administered, preferably on days 5-9. The second test is conducted on days 9-10. The test results are most conveniently compared by colorimetric methods involving monoclonal antibody reactions with follicle stimulating hormone and/or luteininizing hormone.

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Baier, H., et al., "Effect of Clomiphene on Plasma FSH-Activity"; Chem. Abst. 70, p. 50, #103396h (1969).
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Giustina, G., et al., "Clomiphene-induced Modifications of Plasma LH. . . ", Chem. Abst., 76, p. 60, #135965h, (1972).
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Badawi et al.-Chem, Abst. vol. 102 (1985) p. 40276a.

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