Ferritin fusion proteins for use in vaccines and other...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide

Reexamination Certificate

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C424S185100, C424S186100, C424S188100, C424S221100, C424S178100, C424S134100, C530S350000, C530S400000, C530S387300, C514S002600, C514S006900, C536S023400, C435S262000

Reexamination Certificate

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07608268

ABSTRACT:
An isolated ferritin fusion protein is provided in which ferritin is fused with a protein or peptide capable of being fused to ferritin without interfering with the polymeric self-assembly of the resulting fusion protein, and the protein may be of the endocapsid form when fused at the C terminus or an exocapsid form when fused at the N terminus. These fusion proteins may self-assemble into a variety of useful higher polymeric forms, e.g., capsid or other polymeric aggregate, and they are advantageous in that they are useful in a variety of applications, including human and veterinary vaccines and therapeutics, blood substitutes, image contrast agents, metal chelating agents, gelling agents, protein purification platforms, and therapeutic receptor-binding proteins.

REFERENCES:
patent: 7097841 (2006-08-01), Carter et al.
Meola et at (Journal of Immunology 154: 3162-3172, 1995).
Sidoli et al (Journal of Biological Chemistry 268:21819-21825, 1993).
Kim et al (Biochemical and Biophysical Research Communications 289:125-129, 2001).
Luzzago et al (EMBO Journal 8: 569-576, 1989).
Von Darl et al (European Journal of Biochemistry 222:367-376, 1994).
Harrison et al. Biochimica et Biophysica Acta 1275:161-203, 1996.
Meola A. et al, “Derivation of vaccines from mimotopes: immunologic properties of human hepatitis B virus surface antigen mimotopes displayed on filamentous phage” 1995, pp. 3162-3172, vol. 154, No. 7, Journal of Immunology.

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