Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide
Reexamination Certificate
2006-03-14
2009-10-27
Mosher, Mary E (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fusion protein or fusion polypeptide
C424S185100, C424S186100, C424S188100, C424S221100, C424S178100, C424S134100, C530S350000, C530S400000, C530S387300, C514S002600, C514S006900, C536S023400, C435S262000
Reexamination Certificate
active
07608268
ABSTRACT:
An isolated ferritin fusion protein is provided in which ferritin is fused with a protein or peptide capable of being fused to ferritin without interfering with the polymeric self-assembly of the resulting fusion protein, and the protein may be of the endocapsid form when fused at the C terminus or an exocapsid form when fused at the N terminus. These fusion proteins may self-assemble into a variety of useful higher polymeric forms, e.g., capsid or other polymeric aggregate, and they are advantageous in that they are useful in a variety of applications, including human and veterinary vaccines and therapeutics, blood substitutes, image contrast agents, metal chelating agents, gelling agents, protein purification platforms, and therapeutic receptor-binding proteins.
REFERENCES:
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Meola A. et al, “Derivation of vaccines from mimotopes: immunologic properties of human hepatitis B virus surface antigen mimotopes displayed on filamentous phage” 1995, pp. 3162-3172, vol. 154, No. 7, Journal of Immunology.
Carter Daniel C.
Li Chester Q.
Mosher Mary E
New Century Pharmaceuticals Inc.
Schulman B. Aaron
Stites & Harbison PLLC
Wright Terry L.
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