Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1985-01-04
1987-01-20
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
436173, 436806, 128653, 128654, 556146, A61K 4900, A61B 505, A61B 600
Patent
active
046379290
ABSTRACT:
The Ferrioxamine (FOM) family of chelates and amide homologs thereof provide excellent contrast agents for magnetic resonance (MR) imaging. The magnetic dipole generated by unpaired electrons within the paramagnetic Fe(III) atoms, cause a local reduction in the bulk magnetic field Bz of the MR system. The resulting shorting of the T1 (spin lattice) relaxation time in the local hydrogen protons within the area of interest, causes an intense "free induction signal" and a corresponding modulation in the collected scanning data. The contrast agent within the tissue or organ of interest causes the tissue to appear on the MR display as a high intensity or white area. Background tissue is displayed as darker or lower intensity greys.
FOM does not penetrate the blood-brain-barrier under normal circumstances; and is therefore useful in detecting the extravasation of arterial blood in the extravascular space during cerebral hemorrhaging and in the endema fluid surrounding tumors. The amide homologs form functional groups which enable the FOM contrast agents to go into solution readily, and promote organ selectivity.
REFERENCES:
patent: 3471476 (1969-10-01), Gaeumann et al.
Pykett, I., Scientific American, May 1982, pp. 78-88.
Nucker Christine M.
Salutar Inc.
Wieder Stephen C.
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