Ferrioxamine paramagnetic contrast agents for MR imaging

Details Ferrioxamine paramagnetic contrast agents for MR imaging Ferrioxamine paramagnetic contrast agents for MR imaging

1986-02-06

1988-07-19

Warden, Robert J.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 11, 436173, 436806, 128653, 128654, 514492, 534 10, 534 15, 556 45, A61K 4900, A61B 505, A61B 600

Patent

active

047584220

ABSTRACT:
In the NMR imaging of a subject comprising administering to such subject a composition containing an image-modifying effective amount of an image enhancer, permitting the enhancer to move through the subject, and after a time interval taking an NMR image of the subject, the improvement which comprises employing as said enhancer a complex of an oxamine and a polyvalent paramagnetic metal, e.g. ferrioxamine. Novel complexes of trihydroxamic acids, optionally N-acylated, with polyvalent metals other than iron, are also described.

REFERENCES:
patent: 3471476 (1969-10-01), Gaeumann et al.
patent: 4647447 (1987-03-01), Gries et al.
Yunice et al., Arch. Environ. Health, vol. 16, (1968) pp. 163-170.
Chemical Abstracts, 68: 67581n.

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