Fermentative production of D(-)-.beta.-hydroxyisobutyric acid

Details Fermentative production of D(-)-.beta.-hydroxyisobutyric acid Fermentative production of D(-)-.beta.-hydroxyisobutyric acid

1980-10-27

1982-01-12

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435911, 435913, 435917, 435921, 435938, 435940, 435942, C12P 742

Patent

active

043106358

ABSTRACT:
A process is disclosed wherein D(-)-.beta.-hydroxyisobutyric acid is produced fermentatively from isobutyric acid or methacrylic acid by the stereoselective action of microorganisms having the ability to convert isobutyric acid or methacrylic acid into D(-)-.beta.-hydroxyisobutyric acid in an aqueous medium, and D(-)-.beta.-hydroxyisobutyric acid is recovered from the aqueous medium.

REFERENCES:
patent: 3553081 (1971-01-01), Goodhue et al.
patent: 4211846 (1980-07-01), Lafferty
Methods in Enzymology, vol. 6, pp. 552-553 (1963).
Biochemische Zietschrift 1965, vol. 342, pp. 256-271.
Journal of Biological Chemistry, 1966, vol. 241, pp. 868-871.
Biotechnology and Bioengineering, 1971, vol. 13, pp. 203-214.

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