Fermentative process for preparing antibiotics of the gentamicin

Details Fermentative process for preparing antibiotics of the gentamicin Fermentative process for preparing antibiotics of the gentamicin

1979-11-13

1981-09-08

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435869, C12P 1948

Patent

active

042885477

ABSTRACT:
2-Hydroxygentamicins B, B.sub.1 and A.sub.3 and 2-hydroxy antibiotics JI-20A and JI-20B are prepared as fermentation products by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and D-streptamine with a mutant of Micromonospora purpurea, and isolating the said fermentation products from the nutrient medium; the fermentation products are acylated with an ester of an .omega.-(N-benzyloxycarbonyl)amino-.alpha.-hydroxy-lower-alkanoic acid, after first blocking the 6'- and/or 2'-amine group with an amine-protecting group, followed by catalytic hydrogenolysis of the benzyloxycarbonyl group and removal of the amine-protecting groups to prepare the 1-N-(.omega.-amino-.alpha.-hydroxy-lower-alkanoyl) derivatives.

REFERENCES:
patent: 3903072 (1975-09-01), Ilavsky et al.
patent: 3915955 (1975-10-01), Cooper et al.
patent: 3972930 (1976-08-01), Daum et al.
patent: 3982996 (1976-09-01), Daum et al.
patent: 3986929 (1976-10-01), Ilavsky et al.
patent: 4000261 (1976-12-01), Daniels
patent: 4117221 (1978-09-01), Daniels

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