Fermentative preparation process for and crystal forms of...

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

Reexamination Certificate

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C435S118000, C435S252100, C514S365000, C548S203000, C548S204000

Reexamination Certificate

active

07101702

ABSTRACT:
The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.

REFERENCES:
patent: 3459731 (1969-08-01), Gramera et al.
patent: 4383992 (1983-05-01), Lipari
patent: 4535152 (1985-08-01), Szeijtli et al.
patent: 4659696 (1987-04-01), Hirai et al.
patent: 4987072 (1991-01-01), Reichenbach et al.
patent: 5496804 (1996-03-01), Reed et al.
patent: 5565478 (1996-10-01), Kohn et al.
patent: 5641803 (1997-06-01), Carretta et al.
patent: 6194181 (2001-02-01), Hofmann et al.
patent: 6262094 (2001-07-01), Hoefle et al.
patent: 6946561 (2005-09-01), Kusters et al.
patent: 1222697 (1987-06-01), None
patent: 31 182 18 (1982-04-01), None
patent: 33 170 64 (1984-11-01), None
patent: 33 461 23 (1985-06-01), None
patent: 41 38 042 (1993-05-01), None
patent: 42 07 922 (1993-09-01), None
patent: 0 094 157 (1983-11-01), None
patent: 0 149 197 (1985-07-01), None
patent: 0 197 571 (1986-10-01), None
patent: 0 091 781 (1986-11-01), None
patent: 0 292 050 (1988-11-01), None
patent: 0 300 526 (1989-01-01), None
patent: 0 320 032 (1989-06-01), None
patent: 0 396 184 (1990-11-01), None
patent: 0 499 322 (1992-08-01), None
patent: 0 503 710 (1992-09-01), None
patent: 0 636 634 (1995-02-01), None
patent: 0 818 469 (1998-01-01), None
patent: 2189245 (1987-10-01), None
patent: WO 90/12035 (1990-10-01), None
patent: WO 91/07967 (1991-06-01), None
patent: WO 91/11200 (1991-08-01), None
patent: WO 93/10121 (1993-05-01), None
patent: WO 93/19061 (1993-09-01), None
patent: WO 93/23017 (1993-11-01), None
patent: WO 94/26728 (1994-11-01), None
patent: WO 95/08993 (1995-04-01), None
patent: WO 95/31178 (1995-11-01), None
patent: WO 96/14090 (1996-05-01), None
patent: WO 97/18839 (1997-05-01), None
patent: WO 97/19086 (1997-05-01), None
patent: WO 98/08849 (1998-03-01), None
patent: WO 98/22461 (1998-05-01), None
patent: WO 98/25929 (1998-06-01), None
patent: WO 99/01124 (1999-01-01), None
patent: WO 99/02514 (1999-01-01), None
patent: WO 99/07692 (1999-02-01), None
patent: WO 99/65913 (1999-12-01), None
Bollag et al.,Cancer Res., vol. 55, pp. 2326-2333 (1995).
Chemical Abstracts, 98:124208s, Koho, JP 57,194,787, Nov. 30, 1982.
Chemical Abstracts, 96:223270w, Koho, JP 8,224,312, Jan. 30, 1982.
Gerth et al.,J. Antibiotics, vol. 49, No. 6, pp. 560-562 (1996).
Hoefle et al.,Angew. Chem., vol. 108, No. 13/14, pp. 1671-1673 (1996).
Hofle et al., “Epothilone A and B—Novel 16-Membered Macrolides With Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution”,Angew. Chem. Int. Ed. Engl., vol. 35 (13/14), pp. 1567-1569, (1996).
Horikoshi,Chemical Economy Engineering Rev., vol. 13, Nos. 1-2 (140-145), pp. 7-11 (1981).
Loftsson et al.,J. Pharma. Sci., vol. 85, No. 10, pp. 1017-1025 (1996).
May et al., “Total Synthesis of (-) Epothilone B”,Chem. Commun., pp. 1597-1598 (1998).
Meng et al.,J. Am. Chem. Soc., vol. 119, pp. 10073-10092 (1997).
Nicolaou et al.,J. Am. Chem. Soc., vol. 119, pp. 7974-7991 (1997).
Nicolaou et al.,Nature, vol. 387, pp. 268-272 (1997).
Rajewski et al.,J. Pharma. Sci., vol. 85, No. 11, pp. 1142-1169 (1996).
Rowinski,Ann. Rev. Med., vol. 48, pp. 353-374 (1997).

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