Fermentation system and failure-detection probe holder

Details Fermentation system and failure-detection probe holder Fermentation system and failure-detection probe holder

1980-06-11

1982-01-05

Warden, Robert J.

Chemistry: molecular biology and microbiology

Apparatus

Bioreactor

435287, 435289, 435290, C12M 134

Patent

active

043095062

ABSTRACT:
A system for the preparation of biological agents can include a vessel in which the biological agents are fermented and in which the fermentation is monitored by a probe detection means. Probe support means are fastened to the wall of the vessel to support the probe detection means with its operative end within the vessel and to provide access from outside the vessel to the output of the probe detection means. The probe support means has a seal-engaging surface at its forwardmost end within the tank. A seal is seated on the probe detection means forwardly of probe support means, and a seal compression member is fastened to the probe support means to compress the seal between the seal-engaging surface of the probe support means, the seal compression means, and the outer surface of the probe detection means to limit the collection of fermentation material to the exposed outer surfaces of the system and permit cleansing and sterilization of the system. The probe-support means is provided with an open passageway leading from behind the seal to outside of the vessel to permit detection of failure of the system.

REFERENCES:
patent: 3954565 (1976-05-01), Bocko et al.
patent: 4021120 (1977-05-01), Muller et al.
Dr. Ingold, Specification E 764-31B/70, 1963 Zurich, Switzerland, p. 2096, distributed by Chemapec, Inc., Hoboken, New Jersey.
Dr. Ingold, E-764-20 Pressurized Straight Flow Assembly Unit, 764-20/764-31. Distributed by Chemapec, Inc., Hoboken, New Jersey.
Dr. W. Ingold, "Pressurized Elbow Flow Assembly Unit", 712-11/764-32.
Dr. Ingold, E764-INF "Industrial pH Measurement Using Pressurized Immersion Assemblies," Distributed by Chemapec, Inc., Hoboken, New Jersey, pp. 1-2.
"Ingold Threaded Nipples, Blind Plugs and Protector Shields," Distributed by Chemapec, Inc., Hoboken, New Jersey, pp. 1-5.
Arthur H. Thomas Company, Scientific Apparatus and Reagents, Nov. 1968, vol. 5, No. 1, pp. 1-4.

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