Fermentation process using specific oxygen uptake rates as a...

Details Fermentation process using specific oxygen uptake rates as a... Fermentation process using specific oxygen uptake rates as a...

2007-06-19

2007-06-19

Guzo, David (Department: 1636)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

C435S007310, C435S132000, C435S136000

Reexamination Certificate

active

10449911

ABSTRACT:
Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.

REFERENCES:
patent: WO 00/71738 (2000-11-01), None
patent: WO 02/42471 (2002-05-01), None
CARPLUS 1995:627242, Hack et al., The use of oxygen uptake rate to optimize air feed rate to a continuous ethanol fermentation.
Porro et al., Development of Metabolically EngineeredSaccharomyces cerevisiaeCells for the Production of Lactic Acid. Bioctechnol. Prog. 1995. pp. 294-298 vol. 11.
Porro et al., “Replacement of a Metabolic Pathway for Large-scale Production of Lactic Acid from Engineered Yeasts” Appl. and Envtl. Micro. 1999. pp. 4211-4215. vol. 65(9).
Bianchi et al., Efficient Homolactic Fermentation byKluyveromyces lactisStrains Defective in Pyruvate Utilization and Transformed with Heterologous LDH Gene. Appl. and Envtl Micro. 2001. pp. 5621-5625. vol. 67(12).

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