Fermentation process of preparing demethyl maytansinoids

Details Fermentation process of preparing demethyl maytansinoids Fermentation process of preparing demethyl maytansinoids

1981-08-07

1982-11-30

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

C12P 1718

Patent

active

043616500

ABSTRACT:
Novel demethylmaytansinoids representable by the formula: ##STR1## (wherein X is Cl or H; R.sub.1 is H or acyl group) are produced from maytansinoids by means of enzymic transformation. The demethylmaytansinoids are useful as antifungal, antiprotozoal or antitumor agents.

REFERENCES:
patent: 4151042 (1979-04-01), Higashide et al.
patent: 4225494 (1980-09-01), Higashide et al.
patent: 4322348 (1982-03-01), Asai et al.

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