Fermentation process for the production of (+)-2-(5.beta.-n-buty

Details Fermentation process for the production of (+)-2-(5.beta.-n-buty Fermentation process for the production of (+)-2-(5.beta.-n-buty

1977-12-27

1979-12-11

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435933, C12D 1300

Patent

active

041782135

ABSTRACT:
The invention concerns a fermentation process for the production of (+)-2-(5.beta.-n-butyl-4.beta.-hydroxy-2-oxo-tetrahydrofuran-3.beta.-yl)-2 .alpha.-methylacetic acid, which compound has useful ulcer-healing properties. The process is characterised by cultivating an organism known to produce dihydrocanadensolide, such as Penicillium canadense, under generally conventional conditions and then extracting the culture filtrate at a pH in the range pH 3.0-7.0 with a suitable solvent, such as ethyl acetate, and then evaporating the extract to dryness. In a preferred embodiment the extraction is carried out on the culture filtrate at pH 4.0-4.5.

REFERENCES:
patent: 3930014 (1975-12-01), Aldridge et al.
McCorkindale et al., Tetrahedron Letters (1968), pp. 727-730.
Roy, Ph.P. Thesis University of Glasgow, pp. 154-158 (1970).
Birch et al., Australian J. Chemistry, vol. 21, pp. 2775-2784 (1968).

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