Fermentation process for the preparation of novel C.25 (substitu

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

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435886, C12R 1465, C12P 1718, A61K 3137

Patent

active

050266438

ABSTRACT:
Antiparasitic milbemycin derivatives having at the C.25 position a substituted 2-propenyl group --C(CH.sub.3).dbd.CH--R.sup.2 wherein R.sup.2 is a C.sub.3 -C.sub.8 alkyl, alkenyl or alkynyl group which may optionally contain an oxygen or sulphur atom as part of the chain, or a C.sub.3 -C.sub.8 cycloalkyl or cycloalkenyl group, or a 3 to 6 membered oxygen or sulphur containing heterocyclic ring which may optionally be substituted by one or more alkyl groups or halogen atoms; and process for their preparation.

REFERENCES:
patent: 4696922 (1987-09-01), Sturm et al.
patent: 4927847 (1990-05-01), Dutton et al.
patent: 4929638 (1990-05-01), Dutton et al.

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