Fermentation process for producing demycinosyltylosin

Details Fermentation process for producing demycinosyltylosin Fermentation process for producing demycinosyltylosin

1981-05-06

1983-12-06

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435896, C12P 1962, C12R 154

Patent

active

044194471

ABSTRACT:
23-Demycinosyltylosin (DMT) which has the formula: ##STR1## 20-dihydro-DMT, specified acyl ester derivatives, and their acid addition salts are useful antibacterial agents. Improved methods of making 5-O-mycaminosyltylonolide (OMT) and 20-dihydro-OMT by mild acid hydrolysis of DMT and 20-dihydro-DMT, respectively, are included.

REFERENCES:
patent: 3178341 (1965-04-01), Hamill et al.
patent: 3326759 (1967-06-01), Hamill et al.
patent: 3344024 (1967-09-01), Whaley et al.
patent: 3459853 (1969-08-01), Gorman et al.
patent: 4056616 (1977-11-01), Reimann et al.
patent: 4161523 (1979-07-01), Weinstein et al.
patent: 4196280 (1980-04-01), Umezawa et al.
patent: 4205163 (1980-05-01), Mori et al.
Kinumaki et al., "Macrolide Antibiotics M-4365 Produced by Micromonospora II", J. Antibiotics 30 (6) 450-454 (1977).
Tanabe Pharmaceutical, Derwent Abstract 86252X/46 of Japanese Examined Patent 6037-351.
Yamaguchi et al., "Macrolide Antibiotics M-4365 Produced by Micromonospora III. In Vitro Antimicrobial Activity of Antibiotic M-4365G.sub.2 (De-epoxy Rosamicin)", J. Antibiotics 31 (5) 433-440 (1978).
Tanabe Pharmaceutical, Derwent Abstract 86253X/46 of Japanese Examined Patent 6037-352.
Tsukiura et al., "Studies on Cirramycin A.sub.1. III. Structure of Cirramycin A.sub.1 ", J. Antibiotics 22 (3) 89-99 (1969).
Suzuki et al., "A New Condensate Obtained from the Aglycone Moiety of Antibiotic B-58941", Chemistry Letters 1973, 793-798.
Nash et al., "A6888, A New Macrolide Complex Related to the Cirramycins", Current Chemotherapy and Infectious Disease Proceedings of 11th ICC and the 19th ICAAC, American Society of Microbiology, pp. 462-463 (1980).
Nagel et al., "Selective Cleavage of the Mycinose Sugar from the Macrolide Antibiotic Tylosin: A Unique Glycosidic Scission", J. Org. Chem. 44 (12) 2050-2052 (1979).
Masamune et al., "Tylonolide Hemiacetal, the Aglycone of Tylosin and its Partial Synthesis", J. Amer. Chem. Soc. 98 (24) 7874-7875 (1976)
Okamoto et al., Abstract from Chem. Abstr. 93: 68863u (1980) of Japanese Kokai Tokkyo Koho 80 43,0183.

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