Fermentation process for preparing erythritol using mutant cells

Details Fermentation process for preparing erythritol using mutant cells Fermentation process for preparing erythritol using mutant cells

1998-02-10

1999-11-23

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435911, C12P 718

Patent

active

059898780

ABSTRACT:
The present invention relates to a fermentation process for preparing erythritol with high productivity with novel mutant of Trigonopsis variabilis, more specifically, for preparing erythritol under optimal fermentation conditions for maximum erythritol production by optimizing the environmental conditions of culture such as pH, temperature and controlling osmotic pressure. A two-stage fermentation was performed to control osmotic pressure. Osmotic pressure was adjusted to a low level during growth phase and to a high level during production phase by adding glucose and NaCl. Therefore, erythritol production could be increased due to the increased mutant cells.

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Aoki et al., Biotechnology Letters, 15:4, pp. 383-388, Apr. 1993.
Ishizuka et al., Journal of Fermentation and Bioengineering, 68:5, pp. 310-314, 1989.
Hajny et al., Applied Microbiology, 12:2, pp. 240-246, May 1964.

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