Fermentation method for producing norleucine

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435113, 435116, 43525233, 4352528, 435849, C12N 120, C12P 1304, C12P 1306

Patent

active

056228457

ABSTRACT:
The present invention provides an inexpensive fermentation medium for growing microorganisms. Also provided are fermentation media and methods for producing norleucine by growing E. coli thereon, fermentation media and methods for incorporating norleucine into polypeptides expressed by microorganisms grown thereon, and fermentation media and methods for preventing the incorporation of norleucine into polypeptides expressed by microorganisms grown thereon. Also provided are bovine somatotropin analogs.

REFERENCES:
patent: 4562175 (1985-12-01), Chang et al.
patent: 4731440 (1988-03-01), Bentle et al.
J.S. Harris and H.I. Kohn, J. Pharmacol., 73, pp. 383-400 (1941).
J.O. Lampen and M.J. Jones, Arch. Biochem. Biophys., 13, pp. 47-53 (1947).
R. Munier and G.N. Cohen, Biochim. Biophys. Acta., 31, pp. 378-390 (1959).
D.G. Barker and C.J. Bruton, J. Mol. Biol., 133, pp. 217-231 (1979).
B. Nisman and M.L. Hirsch, Ann. Inst. Pasteur, 95, pp. 615-634 (1958).
J.M. Old and D.S. Jones, Biochem. J., 165, pp. 367-373 (1977).
J. Trupin et al., Biochem. Biophys. Res. Comm., 24, pp. 50-55 (1966).
A.R. Fersht and C. Dingwall, Biochem., 18, pp. 1250-1256 (1979).
S.S. Kerwar and H. Weissbach, Arch. Biochem. Biophys., 141, pp. 525-532 (1970).
E. Abderhalden and K. Heyns, Zwitschr. Physiol. Chem., 214, pp. 262-266 (1933).
R. Nuccorini, Ann. Chim. Appl., 24, pp. 25-32 (1934).
P. Nandi and G.P. Sen, Nature, 171, pp. 871-872 (1953).
M. Kisumi, et al., J. Biochem., 80, pp. 333-339 (1976).
M. Kisumi et al., Appl. Environ. Microbiol., 34, pp. 135-138 (1977).
George, H.J. et al., "High-Level Expression in Escherichia coli of Biologically Active Bovine Growth Hormone," DNA, 4(4):273-281 (1985).
Tokunaga, T. et al., "Expression of a synthetic human growth hormone gene in yeast," Gene, 39:117-120 (1985).
Cohen, G.N. et al., "Biosynthesis of Threonine, Lysine, and Methionine," in Escherichia and Salmonella Typhimurium, F.C. Neidhardt, ed. 429-444 (1987).
Naider, F., et al., "Reversible Alkylation of a Methionyl Residue near the Active Site of .beta.-Galactosidase," Biochemistry, 11, pp. 3202-3208 (1972).
Barker, D.G. and Bruton, C.J., "The Fate of Norleucine as a Replacement for Methionine in Protein Synthesis," J. Mol. Biol., 133, pp. 217-231 (1979).
Brown, J.L., "The Modification of the Amino Terminal Region of Escherichia coli Proteins After Initiation with Methionine Analogues," Biochemica et Biophysica Acta, 294, pp. 527-529 (1973).
Tsai, L.B., et al., "Control of Misincorporation of De Novo Synthesized Norleucine into Recombinant Interleukin-2 in E. coli," Biochemical and Biophysical Research Communications, 156, pp. 733-739 (1988).
Gilles, A.M., et al., "Conservative Replacement of Methionine by Norleucine in Escherichia coli Adenylate Kinase," J. Biol. Chem., 263, pp. 8204-8209 (1988).
Bogosian, G., et al., "Biosynthesis and Incorporation into Protein of Norleucine by Escherichia coli," J. Biol. Chem., 264, pp. 531-539 (1989).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Fermentation method for producing norleucine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fermentation method for producing norleucine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fermentation method for producing norleucine will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-340910

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.