Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1986-11-21
1988-08-09
Bond, Robert T.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
514183, 435120, C07D49816, A61K 3142, C12P 1714
Patent
active
047629231
ABSTRACT:
Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III, and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527, while the analog of Formula II is produced by chemical synthesis.
REFERENCES:
patent: 2990325 (1967-06-01), Donovick et al.
patent: 3325359 (1967-06-01), De Somer et al.
patent: 4590004 (1986-05-01), Corbet et al.
patent: 4668669 (1987-05-01), Barriere et al.
Matsen and Barry, Manual of Clinical Microbiology, Lennette, Spaulding, and Truant, Eds., American Society for Microbiology, Washington, DC, pp. 418-427 (1914).
Mutt, Gastrointestinal Hormones, Glass, Ed. Raven Press, N.Y. pp. 169-221 (1980).
Ohyama, Hokkaido J. Med. Sci. 60: pp. 206-216 (1985).
Praissman et al., J. Receptor Res. 3: pp. 647-665 (1983).
Prang et al., Ann. Rep. Med. Chem. 17: pp. 31-40 (1982).
Saito et al., J. Neurochem, 37: pp. 483-490 (1981).
Smith, Eating and Its Disorders, Stunkard and Steller, Eds. Raven Press, N.Y. pp. 67-75 (1984).
Walsh and Grossman, New Engl. J. Med. 292: pp. 1324-1334 (1975).
Chew and Hersey, Am. J. Physiol. 242: pp. G504-512 (1982).
Cocito, Micro. Rev 43: pp. 145-198 (1979).
Faris et al., Science 226: pp. 1215-1217 (1984).
Innis and Snyder, Proc. Natl. Acad. Sci. USA 77: pp. 6917-6921 (1980).
Jensen et al., Proc. Natl. Acad. Sci. USA 77: pp. 2079-2083 (1980).
Kingston et al., J. Chem. Soc. 19: pp. 1669-1676 (1966).
Chang Raymond S.
Hensens Otto D.
Lam Yiu-kuen T.
Schwartz Cheryl D.
Zink Deborah L.
Bond Robert T.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Tribble Jack L.
LandOfFree
Fermentation analogs of virginiamycin M1 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fermentation analogs of virginiamycin M1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fermentation analogs of virginiamycin M1 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-919453