Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-06-03
1993-02-23
Friedman, S. J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3142
Patent
active
051890500
ABSTRACT:
Pharmaceutical compositions containing Virginiamycin M.sub.1 having the Formula: ##STR1## and Virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## are disclosed which are useful in the treatment of panic disorder or anxiety disorder.
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Bradwejn, et al., Enhanced Sensitivity to Cholecystokinin Tetrapeptide in Panic Disorder, Soc. Neurosci. Abstr. 14(1), p. 291, (1988).
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Breadwejn, et al., Benzodiazepines Antagonize Cholecystokinin-Induced Activation of Rat Hippocampal, Nature 312, p. 22, (1984).
de Montigny, Cholecystokinin Tetrapeptide Induces Panic-like Attacks in Healthy Volunteers, Arch. Gen. Psychiatry, 46, (1989).
Dourish, et al., Morphine Induced Analgesia in the Rat Paw Pressure Test is Blocked by CCK and Enhanced by the CCK Antagonist MK-329, Eur. Jour. Pharm. 147, No. 3, pp. 469-472, (1988).
Bouthillier, et al., Long-term Benzodiazepine Treatment Reduces Neuronal Responsiveness to Cholecystokinin: an Electrophysiological Study in the Rat, Eur. Jour. Pharm. 151, No. 1, pp. 135-138, (1988).
U.S. Serial No. 07/852,478, Freidinger et al., filed Mar. 12, 1992.
Bock Mark G.
Chang Raymond S.
Freidinger Roger M.
Hensens Otto D.
Lam Yiu-kuen T.
Daniel Mark R.
DiPrima Joseph F.
Friedman S. J.
Merck & Co. , Inc.
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