Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1989-10-26
1991-04-09
Brown, Johnnie R.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435119, 4352535, 435902, 435886, 514183, C12P 1718, C12P 1714, C12N 100, C12N 120
Patent
active
050064665
ABSTRACT:
Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527, while the analog of Formula II is produced by chemical synthesis.
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patent: 4772595 (1988-09-01), Lam et al.
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Chemical Abstracts, vol. 77, No. 5, Jul. 31, 1972, p. 375, #32682e.
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Chang Raymond S.
Hensens Otto D.
Lam Yiu-kuen T.
Schwartz Cheryl D.
Zink Deborah L.
Brown Johnnie R.
Harbour John W.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Speer Raymond M.
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