Fenofibrate pharmaceutical composition having high bioavailabili

Details Fenofibrate pharmaceutical composition having high bioavailabili Fenofibrate pharmaceutical composition having high bioavailabili

1998-01-09

2000-06-13

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424456, 424458, 424459, 424489, 424490, 424497, 424464, 424465, 424469, 424470, A61K 916, A61K 920, A61K 950

Patent

active

06074670&

ABSTRACT:
The invention provides an immediate-release fenofibrate composition comprising (a) an inert hydrosoluble carrier covered with at least one layer containing fenofibrate in a micronized form having a size less than 20 .mu.m, a hydrophilic polymer and, optionally, a surfactant, the polymer making up at least 20% by weight of (a); and (b) optionally one or several outer phase(s) or layers(s). The invention also provides a method for preparing said composition.

REFERENCES:
patent: 4412986 (1983-11-01), Kawata et al.
patent: 4800079 (1989-01-01), Boyer
patent: 4895726 (1990-01-01), Curtet et al.
patent: 4992277 (1991-02-01), Sangekar et al.
patent: 5545628 (1996-08-01), Deboeck et al.
patent: 5776495 (1998-07-01), Duclos et al.
Temeljotov et al., Solubilization and Dissolution Enhancement for Sparingly Soluble Fenofibrate, Acta Pharm., 46 pp 131-136, 1996.

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