Fenamic acid hydroxamate derivatives having cyclooxygenase and 5

Details Fenamic acid hydroxamate derivatives having cyclooxygenase and 5 Fenamic acid hydroxamate derivatives having cyclooxygenase and 5

1988-09-26

1992-10-13

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514418, 514507, 514575, 544285, 544287, 548483, 560315, 562622, C07C25910, A61K 3127

Patent

active

051551101

ABSTRACT:
The present invention is novel selected hydroxamic acid derivatives of fenamic acids having 5-lipoxygenase and cyclooxygenase inhibiting properties, pharmaceutical compositions for treating conditions advantageously affected by the inhibition and methods for treating these conditions in mammals, including humans suffering therefor.

REFERENCES:
patent: 4029815 (1977-06-01), Sherlock
patent: 4906667 (1990-03-01), Varma
Wolf and Kohn; Liebigs Ann. Chem. 1975, 1245-1251 "Cyclisierungsreaktionen von am Aminostickstoff Substituierten o-Aminobenzhydroxamsaure-O-methylestern".
James B. Summers, et al., "Hydroxamic Acid Inhibitors of 5-Lipoxygenase" J. Med. Chem 1987, 30, 574-580.
Summers, et al. "In Vivo Characterization of Hydroxamic Acid Inhibitors of 5-Lipoxygenase" Sep. 1987, (Abstract).

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