Feline interferon

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

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Details

424 854, C07K 14555, A61K 3821

Patent

active

055082912

ABSTRACT:
Purified feline interferon polypeptides are disclosed. A synthetic plasmid in which DNA encoding protein of a feline interferon is integrated, a transformant obtainable by the transformation of a host cell by the use of the synthetic plasmid and a feline interferon having a biological activity given by a protein carrying a specific amino acid sequence, a feline interferon gene encoding the feline interferon, a feline interferon precursor comprised of a cleavable peptide or a signal peptide being linked to the N terminal of the feline interferon, a feline interferon precursor gene encoding the feline interferon precursor and a method for producing the feline interferon, which are applied to the mass production of a feline interferon to be used as a remedy for feline vital disease and tumor.

REFERENCES:
patent: 4861720 (1989-08-01), Pederson et al.
Yasuda et al. Clin. Exp. Immunol 69: pp. 240-245 (1987).
Yasuda et al Prep. Biochem 16(3):217-226 (1986).
Weiss et al. Am. Journal of Vet. Res 49(8): 1329-1335 (1988).
Interferons and their Actions, Stewart, ed. CRC Press, Inc., Boca Raton, p. 50.
177 USPQ 381 (CCPA 1973) In. Re. Davies.
Pestka Arch of Biochem and Biophy 221(1):1-37 (1983).
Yamamoto et al, "A Feline Retrovirus Induced . . . ," Vet. Immunol. and Immunopathol., 11 (1986) pp. 1-19.
Yasuda et al, "Partial purification and characterization . . . ," Prep. Biochem., vol. 16, No. 3, 1986.

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