Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-08-28
2000-06-27
Hutzell, Paula K.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
530350, C07H 2104, C07K 100
Patent
active
060808500
ABSTRACT:
The invention comprises the nucleotide sequences comprising the FIPV S gene, or a fragment of this gene, which are modified in at least one of the antigenic regions A1 and A2 which are involved in enhancement, as well as the use of these sequences for the expression of modified proteins, and for the construction of recombinant viruses or expression plasmids, and the use of the recombinant viruses as vaccines against feline infectious peritonitis, the use of the expression plasmids as immunizing composition by direct injection of the said plasmids into cats, and the use of the modified proteins as vaccine.
REFERENCES:
Jacobs et al. "The nucleotide sequence of the peplomer gene of porcine transmiccible gastroenteritis (TGEV): comparison with the sequence of the peplomer protein of feline infectious peritonitis virus (FIPV)". Virus Research. vol. 8:363-371, 1987.
Correa et al. "Localization of antigenic sites of the E2 glycoprotein of transmissible gastroenteritis coronavirus". Journal of General Virology. vol. 71:271-279, 1990.
Ellis et al. "New Technologies for Making Vaccines". Vaccines. Plotkin et al., Eds. Chapter 29. pp. 568-575, 1988.
Monoclonal Antibodies to the Spike Protein of Feline Infectious Peritonitis Virus Mediate Antibody-Dependent Enhancement of Infection of Feline Macrophages; Journal of Virology, Feb. 1992, vol. 66, No. 2, P 956-965.
Early Death after Feline Peritonitis Virus Challenge due to Recombinant Vaccinia Virus Immunization; Journal of Virology, Mar. 1990; vol. 63, No. 3 p. 1407-1409.
Journal of General Virology, vol. 74, 1993 Reading, GB, pp. 745-749; Olsen C. et al; "Identification of antigenic sited mediating antibody-dependent enhancement of feline infectious peritonitis viris infectivity".
Journal of Virology, vol. 66 No. 11, Nov. 1992, pp. 6695-6705; Corapi, W. et al; "Monoclonal antibody analysis of neurtralization and antibody-dependent enhancement of feline infectious peritonitis virus".
Journal of General Virology, vol. 68, No. 10, Oct. 1987; Reading, GB, pp. 2639-2646, De Groot, R. et al; "cDNA cloning and sequence analysis of the gene encoding the peplomer protein of feline infectious peritonitis virus".
Journal Of Virology, vol. 69, No. 5, May 1995; pp. 2858-2862; Corapi. W. et al; "Localization of antigenic sites of the S glycoprotein of feline infectious peritonitis virus involved in neutralization and antibody-dependant enhancement".
Audonnet Franqis Jean-Christophe
Chappuis Emile Gilles
Corapi Wayne
Darteil Raphael
Brumback Brenda G.
Hutzell Paula K.
Rhone Merieux
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