Feline hepatocyte growth factor

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C530S399000

Reexamination Certificate

active

11450056

ABSTRACT:
A feline hepatocyte growth factor gene and a 15 base pairs-deleted feline hepatocyte growth factor gene. These genes encode a protein having an amino acid sequence shown in SEQ ID NO: 2 or 4.The feline hepatocyte growth factor and the 5 amino acids-deleted feline hepatocyte growth factor are useful for the treatment of liver diseases, kidney diseases, lung diseases, digestive diseases, cardiocirculatory diseases or cranial nerve diseases.

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patent: 6699837 (2004-03-01), Nakamura
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patent: WO94/01548 (1994-01-01), None
Kobayashi et al. Locus AB046610, Jan. 27, 2001. Accessed Mar. 22, 2005 (see attached computer printout).
“Molecular Cloning of Feline Hepatocyte Growth Factor (HGF) cDNA”, J. Vet. Med. Sci., vol. 63, No. 2, pp. 211-214, 2001.
“Deduced primary structure of rat hepatocyte growth factor and expression of the MRNA to rat tissues”, Cell Biology, vol. 87, pp. 3200-3204, 1990.
Nakamura, et al., Molecular Cloning and Expression of Human Hepatocyte Growth Factor, Nature, Macmillan Journals Ltd., London, vol. 342, Nov. 23, 1989, pp. 440-443, XP000652120.
Okigaki, et al., Functional Characterization of Human Hepatocyte Growth Factor Mutants Obtained by Deletion of Structural Domains, Biochemistry, vol. 31, No. 40, 1992, pp. 9555-9561, XP002279003.
“Characterization of the Scatter Factor/Hepatocyte Growth Factor Gene Promoter” The Journal of Biological Chemistry, vol. 270, No. 2, Jan. 1995, pp. 830-836.
“Primary structure of rat hepatocyte growth factor and induction of its MRNA during liver regeneration following hepatic injury”, Eur. J. Biochem. vol. 193., pp. 375-381, 1990.
“Identification of mouse mammary fibroblast-derived mammary growth factor as hepatocyte growth factor”, Biochemical and Biophysical Research Communications, vol. 199, No. 2, pp. 772-779, 1994.
“Molecular cloning and sequence analysis of cDNA for Human Hepatocyte growth factor”, Biochemical and Biophysical Research Communications, vol. 163, No. 2, pp. 967-973, 1989.
Patent Abstracts of Japan, Publication No. 3-204899, corresponding to JP 3-204899 A, Otsuka Pharmaceutical Co., Ltd., Sep. 6, 1991.
“Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor”, Biochimica et Biophysica Acta, vol. 1216, pp. 299-303, 1993.
Molecular Cloning and Chromosomal Mapping of Feline p53 Tumor Suppressor Gene, J. Vet. Med. Sci., vol. 55, No. 5, pp. 801-805, 1993.

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