Feline hepatocyte growth factor

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S320100, C435S252300, C435S325000, C435S006120, C536S023500, C530S350000

Reexamination Certificate

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07125688

ABSTRACT:
A feline hepatocyte growth factor gene and a 15 base pairs-deleted feline hepatocyte growth factor gene. These genes encode a protein having an amino acid sequence shown in SEQ ID NO: 2 or 4. The feline hepatocyte growth factor and the 5 amino acids-deleted feline hepatocyte growth factor are useful for the treatment of liver diseases, kidney diseases, lung diseases, digestive diseases, cardiocirculatory diseases or cranial nerve diseases.

REFERENCES:
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patent: WO 94/01548 (1994-01-01), None
Kobayashi et al. Locus AB046610, Jan. 27, 2001. Accessed Mar. 22, 2005 (see attached computer printout).
“Molecular Cloning of Feline Hepatocyte Growth Factor (HGF) cDNA”, J. Vet. Med. Sci., vol. 63, No. 2, pp. 211-214, 2001.
“Deduced primary structure of rat hepatocyte growth factor and expression of the MRNA in rat tissues”, Cell Biology, vol. 87, pp. 3200-3204, 1990.
“Characterization of the Scatter Factor/Hepatocyte Growth Factor Gene Promoter” The Journal of Biological Chemistry, vol. 270, No. 2, Jan. 1995, pp. 830-836.
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“Identification of mouse mammary fibroblast-derived mammary growth factor as hepatocyte growth factor”, Biochemical and Biophysical Research Communications, vol. 199, No. 2, pp. 772-779, 1994.
“Molecular cloning and sequence analysis of cDNA for Human Hepatocyte growth factor”, Biochemical and Biophysical Research Communications, vol. 163, No. 2, pp. 967-973, 1989.
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“Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor”, Biochimica et Biophysica Acta, vol. 1216, pp. 299-303, 1993.
Molecular Cloning and Chromosomal Mapping of Feline p53 Tumor Suppressor Gene, J. Vet. Med. Sci., vol. 55, No. 5, pp. 801-805, 1993.
Nakamura, et al., Molecular Cloning and Expression of Human Hepatocyte Growth Factor, Nature, Macmillan Journals Ltd., London, vol. 342, Nov. 23, 1989, pp. 440-443, XP000652120.
Okigaki, et al., Functional Characterization of Human Hepatocyte Growth Factor Mutants Obtained by Deletion of Structural Domains, Biochemistry, vol. 31, No. 40, 1992, pp. 9555-9561, XP002279003.

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