Feedback-resistant mevalonate kinases

Details Feedback-resistant mevalonate kinases Feedback-resistant mevalonate kinases

2004-06-10

2008-09-09

Swope, Sheridan (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C536S023200, C536S023100, C435S071100, C435S320100, C435S252300, C435S252330, C435S254200, C435S068100

Reexamination Certificate

active

07422884

ABSTRACT:
The present invention relates to modified mevalonate kinases that are less sensitive to feedback inhibition, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for producing the modified enzyme and a method for producing isoprenoid compounds.

REFERENCES:
patent: 6284506 (2001-09-01), Hoshino et al.
patent: WO 02/099095 (2002-12-01), None
Galye et al, Identification of regions in interleukin-1 alpha important for activity. J Biol Chem. Oct. 15, 1993;268(29):22105-11.
Whisstock et al, Prediction of protein function from protein sequence and structure. Q Rev Biophys. Aug. 2003;36(3):307-40. Review.
S.M. Houten et al., “Biochemical and genetic aspects of mevalonate kinase and its deficiency,”Biochimica et Biophysica Acta, vol. 1529, No. 1-3, pp. 19-32 (2000).
M. Hümbelin et al., “Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens,”Gene, vol. 297, No. 1-2, pp. 129-139 (2002).

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