Feedback controlled release

Details Feedback controlled release Feedback controlled release

1987-04-03

1990-08-28

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

514 3, 514 2, A61K 3726, A61F 200

Patent

active

049524062

ABSTRACT:
A controlled release system using a feedback-responsive controller reversibly changes the pH of the aqueous microenvironment of a biologically active compound sequestered in an aqueous-fluid-penetrable, aqueous-insoluble biocompatible material; the pH change is effected in response to a change in the concentration of the target compound in the aqueous medium surrounding the insoluble material; as a result of the pH change, the aqueous solubility and therefore the release rate of the active compound is reversibly changed.

REFERENCES:
patent: 4164560 (1979-08-01), Folkman et al.
patent: 4357312 (1982-11-01), Hsieh et al.
patent: 4364385 (1982-12-01), Lossef
Lym, Science (1980) 210:908.
Levy and Carpenter, Biochemisty, vol. 6, No. 11, Nov. 1967.

Affiliated with

Also associated with

Rating

Feedback controlled release does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Feedback controlled release, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Feedback controlled release will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1588790