Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure
Patent
1979-09-21
1981-03-24
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
A61K 3500
Patent
active
042580315
ABSTRACT:
On feeding both of the antibiotic A3823 complex monensin and the phosphate ester ronnel, i.e., 0,0-dimethyl 0-(2,4,5-trichlorophenyl)phosphorothioate, to livestock and poultry selected from cloven hoof ruminant animals, swine and poultry substantially every day for at least about 3 to about 28 days depending on the animal, and more preferably for a longer period through growth and/or fattening feeding cycles or during maintenance periods, in respective amounts in an effective amount in the range of about 0.14 to about 2.3 milligrams of the antibiotic and about 0.5 to about 4 milligrams of ronnel per kilogram (mg/kg) of body weight per day, the growth of the livestock and poultry takes place at an increased rate; fiber production, such as wool in sheep, is increased; the production of milk in lactating animals is increased; and, in particular, the feed conversion efficiency of the animal is markedly improved compared to the response obtained on providing either of the antibiotic or ronnel alone. The antibiotic and ronnel are provided for oral ingestion by the animal on a voluntary basis upon incorporating sufficient antibiotic and ronnel into a balanced feed diet or a component thereof to provide about 0.14 to about 2.3 mg of antibiotic in addition to about 0.5 to about 4 mg of ronnel per kg of body weight per animal per day on average and substantially every day during the period of nutritional response promotion treatment, prepared feeds typically containing from about 5 to about 100 grams of antibiotic and about 3 to about 200 grams of ronnel per ton of feed (dry matter basis). For range-fed animals, the antibiotic and ronnel are conveniently incorporated in a mineral, protein or energy type feed additive supplement.
Ronnel in the described combination may be replaced in part or entirely, mol for mol, by either of the close analogs bromophos or iodofenphos or a mixture thereof.
REFERENCES:
patent: 2811480 (1957-10-01), Norris, Jr. et al.
patent: 3501568 (1970-03-01), Haney et al.
patent: 3839557 (1974-10-01), Raun
Chemical Abstracts, vol. 83 (1975) p. 108290x.
Chemical Abstracts, vol. 64 (1966) pp. 8085h-8086a.
Chemical Abstracts, vol. 65 (1966) p. 13762a.
Fletcher Donald R.
Tollett James T.
The Dow Chemical Company
Waddell Frederick E.
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