Fecal occult blood test reagents

Details Fecal occult blood test reagents Fecal occult blood test reagents

1990-05-07

1991-10-01

Warden, Robert J.

Chemistry: analytical and immunological testing

Hemoglobin, myoglobin, or occult blood

422 56, 422 57, 422 58, 435 28, 436904, G01N 3349

Patent

active

050533428

ABSTRACT:
An improved method for detecting peroxidatively active materials in a sample is provided, the method incorporating antimalarial drugs such as quinine, quinidine, chloroquine, primaquine, and quinacrine as modulating compounds. In a preferred embodiment, the method is a fecal occult blood test (FOBT), in which a fecal specimen is contacted with a chromogen and a hydroperoxide in the presence of a selected quinoline derivative. The method enables careful modulation of test sensitivity and specificity, and further provides an FOBT in which interference from dietary meat ingestion is substantially eliminated.

REFERENCES:
patent: 2290436 (1942-07-01), Kamlet
patent: 3092464 (1963-07-01), Adams et al.
patent: 3236850 (1966-02-01), Oswald et al.
patent: 3290117 (1966-12-01), Adams et al.
patent: 3721607 (1973-03-01), Gruber et al.
patent: 3876631 (1975-04-01), Hawkins
patent: 3917452 (1975-11-01), Werner et al.
patent: 3932528 (1976-01-01), Suda et al.
patent: 3975161 (1976-08-01), Svoboda et al.
patent: 3986833 (1976-10-01), Mast et al.
patent: 3996006 (1976-12-01), Pagano et al.
patent: 4017261 (1977-04-01), Suoboda et al.
patent: 4063894 (1977-12-01), Ogawa et al.
patent: 4071317 (1978-01-01), Lam
patent: 4088642 (1978-05-01), Sheppard et al.
patent: 4115419 (1978-09-01), Naglieri et al.
patent: 4148611 (1979-04-01), Nand et al.
patent: 4202829 (1980-05-01), DeLucca et al.
patent: 4333734 (1982-06-01), Fleisher
patent: 4386053 (1983-05-01), Motobayashi
patent: 4481295 (1984-11-01), Habenstein
patent: 4556640 (1985-12-01), Gantzer
patent: 4578359 (1986-03-01), Oksman et al.
patent: 4596770 (1986-06-01), Parham et al.
patent: 4615982 (1986-10-01), Lawrence
patent: 4818702 (1989-04-01), Lawrence
patent: 4820646 (1989-04-01), Lawrence
patent: 4937197 (1990-06-01), Lawrence
patent: 4939097 (1990-07-01), Lawrence
patent: 4942132 (1990-07-01), Lawrence
patent: 4971914 (1990-11-01), Lawrence
H. S. Banyal et al, Life Sciences, 31:1141-1144 (1982).
Berezin et al., Chem. Abstracts, vol. 103, No. 76969p (1985).
B. Bhattacharyya et al., Biochemical Pharmacology, 32(19):2965-2968 (1983).
G. Blauer, Arch. Biochem. Biophys., 251(1):306-314 (1986).
A. C. Chou et al., Biochemistry, 19:1543-1549 (1980).
A. C. Chou et al., J. Clin. Invest., 66:856-858 (1980).
S. N. Cohen and K. L. Yielding, J. Biol. Chem., 240(7):3123-3131 (1965).
P. Dutta et al., J. Pharmacol. and Exper. Therap., 225(3):729-734 (1983).
N. L. Etkin and J. W. Eaton, "Malaria-Induced Erythrocyte Oxidant Sensitivity", in Erythrocyte Structure and Function, New York: Alan R. Liss, Inc., 1975.
C. D. Fitch et al., "Ferriprotoporphyrin IX: A Mediator of the Antimalarial Action of Oxidants and 4-Aminoquinoline Drugs", in Malaria and the Red Cell, (New York: Alan R. Liss Inc., 1984), pp. 119-130.
C. D. Fitch et al., Antimicrob. Agents and Chemother., 21(5):819-822 (1982).
C. D. Fitch, "Mode of Actio of Antimalarial Drugs", in Malaria and the Red Cell, (London: Ciba Foundation Symposium94, 1983), pp. 222-232.
H. Foy and A. Kondi, Annals of Trop. Med. Parasitol., 44:309-318 (1950).
D. M. Fraser and W. O. Kermack, Brit. J. Pharmacol., 12:16-23 (1957).
U. Gerlach, Klin. Wschr., 36:376-378 (1958).
F. E. Hahn, in Antibiotics: Mechanism of Action of Antimicrobial and Antitumor Agents, vol. 3, pp. 58-78, ed. Corcoran et al., West Berlin: Springer-Verlag, 1974.
S. K. Janney et al., Blood, 67(2):331-333 (1986).
A. Jearnpipatkul et al., Experientia, 36:1063-1064 (1980).
A. Jearnpipatkul et al., Chem. Biol. Interactions, 33:83-90 (1980).
D. J. Krogstad et al., Am. J. Trop. Med Hg., 36(2):213-220 (1987).
H. Laser et al., Parasitology, 71:167-181 (1975).
P. B. Macomber and H. Sprinz, Nature, 214:937-939 (1967).
S. Moreau et al., Biochimie, 64:1015-1025 (1982).
S. Moreau et al., Biochim. Biophys. Acta., 840:107-116 (1985).
S. V. Otton et al., Experientia, 40:973-974 (1984).
B. Panijpan et al., Bioscience Reports, 3:1113-1117 (1983).
Schwartz et al., Clinical Chemistry, vol. 29, No. 12, pp. 2062-2067.
J. K. Shute et al., Biochem. Pharmacol., 34:2471-2475 (1985).
P. M. L. Siu, Comp. Biochem. Physiol., 23:785-795 (1967).
D. L. Vander Jagt et al., Molecular and Biochemical Parasitology, 10:45-54 (1984).
D. C. Warhurst, Biochemical Pharmacology, 30(24):3323-3327 (1981).

Affiliated with

Also associated with

Rating

Fecal occult blood test reagents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fecal occult blood test reagents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fecal occult blood test reagents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1754645