Fecal occult blood test methods

Details Fecal occult blood test methods Fecal occult blood test methods

1987-12-24

1990-07-03

Hill, Jr., Robert J.

Chemistry: analytical and immunological testing

Hemoglobin, myoglobin, or occult blood

422 56, 435 28, 436169, 436904, G01N 2178, G01N 3372

Patent

active

049390970

ABSTRACT:
An improved method for detecting peroxidatively active materials in a sample is provided, the method incorporating antimalarial drugs such as quinine, quinidine, chloroquine, primaquine, and quinacrine as modulating compounds. In a preferred embodiment, the method is a fecal occult blood test (FOBT), in which a fecal specimen is contacted with a chromogen and a hydroperoxide in the presence of a selected quinoline derivative. The method enables careful modulation of test sensitivity and specificity, and further provides an FOBT in which interference from dietary meat ingestion is substantially eliminated.

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