Febrifugine, isofebrifugine and method for producing the same

Details Febrifugine, isofebrifugine and method for producing the same Febrifugine, isofebrifugine and method for producing the same

2005-01-18

2005-01-18

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S287000

Reexamination Certificate

active

06844350

ABSTRACT:
A febrifugine represented by Formula (A):and an isofebrifugine represented by Formula (B):which exhibit extremely strong activities against tropical malarial protozoan are provided, together with a total synthesis route which enables efficient large scale synthesis of the same.

REFERENCES:
patent: 4762838 (1988-08-01), Glazer
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Burgess, L.E., et al. “The Preparation of α-Substituted, β-Hydroxy Piperidines and pyrrolidines: The Total Synthesis of Febrifugine.”, Tetrahedron Letters, vol. 37, No. 19 (1996), pp. 3255-3258.
Kobayashi, S., et al. “Catalytic Asymmetric Synthesis of Antimalarial Alkaloids Febrifugine and Isofebrifugine and Their Biological Activity”, J. Org. Chem., vol. 64 (1999), pp. 6833-6841.
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