FcγRIIB specific antibodies and methods of use thereof

Details FcγRIIB specific antibodies and methods of use thereof FcγRIIB specific antibodies and methods of use thereof

2008-07-03

2011-10-25

Dahle, Chun (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S387300, C530S387700, C530S388100, C530S388220, C530S388730, C424S130100, C424S133100, C424S141100, C424S142100, C424S143100, C424S144100, C424S152100, C424S153100, C424S172100, C424S174100, C435S325000, C435S326000, C435S328000, C435S335000, C435S344100, C435S346000

Reexamination Certificate

active

08044180

ABSTRACT:
The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.

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