FcγRIIA-specific nucleic acid interference

Details FcγRIIA-specific nucleic acid interference FcγRIIA-specific nucleic acid interference

2004-11-15

2008-05-06

Angell, Jon Eric (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S006120, C435S325000, C435S375000, C514S04400A, C536S023100, C536S024300

Reexamination Certificate

active

07368559

ABSTRACT:
The present invention provides methods and compositions for attenuating expression of FcγRIIA. In general, the described methodology involves the use of RNAi constructs that are targeted to a FcγRIIA mRNA sequence.

REFERENCES:
patent: WO-96/40199 (1996-12-01), None
patent: WO 96/40199 (1996-12-01), None
patent: WO 02/062954 (2002-08-01), None
patent: WO-03/070912 (2003-08-01), None
patent: WO 2004/052364 (2004-06-01), None
patent: WO 2005/007623 (2005-01-01), None
Brooks et al., Structure and Expression of Human IgC FcRII(CD32), 1989, J. Exp. Med., vol. 170, pp. 1369-1385.
Scherer et al., Approaches for the sequence-specific knockdown of mRNA, 2003, Nat. Biotechnol., 21(12), pp. 1457-1465.
Mahato et al., Modulation of gene expression by antisense and antigene oligodeoxynucleotides and small interfering RNA, Jan. 2005, Expert Opinion on Drug Delivery, vol. 2, No. 1, pp. 3-28.
Zhang et al., Targeted Gene Silencing by Small Interfering RNA-Based Knock-Down Technology, 2004, Current Pharmaceutical Biotechnology, vol. 5, p. 1-7.
Elbashir et al., Functional anatomy of siRNAs for mediating efficient RNAi inDrosophila melanogasterembryo lysate, 2001, The EMBO Journal, vol. 20, No. 23, pp. 6877-6888.
Hammond et al., Post-Transcriptional Gene Silencing by Double-Stranded RNA, 2001, Nature Reviews, Genetics, vol. 2, pp. 110-119.
Schmidt et al., Base and sugar requirements for RNA cleavage of essential nucleoside residues in internal loop B of the hairpin ribozyme: implications for secondary structure, 1996, Nucleic Acids Research, vol. 24, No. 4, pp. 573-581.
International Preliminary Report on Patentability and Written Opinion. International Application: PCT/US2004/038192. Mailing date: May 26, 2006.
Takada et al., “Hydrogen Peroxide Activates NF-kB through Tyrosine Phosphorylation of IkBα and Serine Phosphorylation of p65,”Journal of Biological Chemistry278(26):24233-24241 (2003).
Stenton et al., “Aerosolized Syk Antisense Suppresses Syk Expression, Mediator Release from Macrophages, and Pulmonary Inflammation,”The Journal of Immunology164:3790-3797 (2000).
Matsuda et al., “Abrogation of the Feγ Receptor IIA-Mediated Phagocytic Signal by Stem-Loop Syk Antisense Oligonucleotides,”Molecular Biology of the Cell7:1095-1106 (1996.
Lim et al., “Flow Cytometric Monocyte Phagocytic Assay for Predicting Platelet Transfusion Outcome,”Transfusion42:309-316 (2002).
Takada et al., “TNF Activates Syk Protein Tyrosine Kinase Leading to TNF-induced MAPK Activation, NF-κB Activation, and Apoptosis,”The Journal of Immunology173:1066-1077 (2004).
Wiener et al., “Anti-HPA-la-mediated platelet phagocytosis by monocytes in vitro and its inhibition by Fc gamma receptor (FcγR) reactive reagents,”European Journal of Haematology70:67-74 (2003).
Elbashir et al., “Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells,”Nature411:494-498 (2001).
Gregory J. Hannon, “RNA interference,” Nature 418:244-251 (2002).
Elbashir et al., “Functional anatomy of siRNAs for mediating efficient RNAi inDrosophila melanogasterembryo lysate,”The EMBO Journal20(23):6877-6888 (2001).
Paddison et al., “Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells,”Genes&Development16:948-958 (2002).
Soutschek et al., “Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs,”Nature432:173-178 (2004).
Beardsly et al., “Short interfering RNA sequence (RNAi) specific for Syk and FcγRIIA (CD32A) selectively inhibit antibody-mediated platelet phagocytosis by human macrophages,”Blood102(11):86a (2003).

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