FC fusion proteins of human erythropoietin with increased...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S397000, C435S069100, C435S325000, C435S328000, C435S335000

Reexamination Certificate

active

11017185

ABSTRACT:
Fc fusion proteins of human EPO with increased biological activities relative to rHuEPO on a molar basis are disclosed. The HuEPO-L-vFc fusion protein comprises HuEPO, a flexible peptide linker of about 20 or fewer amino acids, and a human IgG Fc variant. The Fc variant is of a non-lytic nature and shows minimal undesirable Fc-mediated side effects. A method is also disclosed to make or produce such fusion proteins at high expression levels. Such HuEPO-L-vFc fusion proteins exhibit extended serum half-life and increased biological activities, leading to improved pharmacokinetics and pharmacodynamics, thus fewer injections will be needed within a period of time.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

FC fusion proteins of human erythropoietin with increased... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with FC fusion proteins of human erythropoietin with increased..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and FC fusion proteins of human erythropoietin with increased... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3724210

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.