Fc fusion proteins for enhancing the immunogenicity of...

Details Fc fusion proteins for enhancing the immunogenicity of... Fc fusion proteins for enhancing the immunogenicity of...

2011-06-07

2011-06-07

Canella, Karen A (Department: 1643)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

C424S192100, C424S085200, C424S134100, C530S351000, C530S387100, C530S387900, C530S389100, C530S391700, C930S141000

Reexamination Certificate

active

07955590

ABSTRACT:
Disclosed herein are methods and compositions for enhancing the immunogenicity of a preselected protein or peptide antigen in a mammal. Immunogenicity is enhanced by fusing the preselected antigen to an immunoglobulin heavy chain constant region to produce an Fc-antigen fusion protein. The Fc-antigen fusion proteins bind Fc receptors on the surface of antigen presenting cells, thereby targeting the antigen to the antigen presenting cells in the mammal. In addition, disclosed is a family of adjuvants, for example, an Fc-adjuvant fusion protein, for use in combination with the Fc-antigen fusion proteins to enhance or modulate a particular immune response against the preselected antigen.

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