Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2007-02-06
2007-02-06
Campell, Bruce R. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S069100, C435S007100
Reexamination Certificate
active
11122373
ABSTRACT:
Agents that modulate an interaction of an FBL2 protein with an NS5A or NS5B Flaviviridae protein in a mixture are identified by contacting the mixture with a candidate agent under conditions wherein but for the presence of the agent, the FBL2 protein and the Flaviviridae protein engage in a reference interaction; and detecting an agent-biased interaction. Flaviviridae replication is inhibited by contacting a Flaviviridae-infected cell with an FBL2-specific reagent; and detecting a resultant Flaviviridae replication inhibition.
REFERENCES:
Wang et al. (“Identification of FBL2 As a Geranylgeranylated Cellular Protein Required for Hepatitis C Virus RNA replication,” Molecular Cell, vol. 18 (pp. 425-434, May 13, 2005).
Brown Michael S.
Gale, Jr. Michael J.
Goldstein Joseph L.
Wang Chunfu
Ye Jin
Board of Regents , The University of Texas System
Campell Bruce R.
Osman Richard Aron
Salvoza M. Franco
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