Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1986-12-24
1987-09-15
Evans, J. E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
260413, 514913, C11C 300, A61K 31045, A61K 31085
Patent
active
046940227
ABSTRACT:
Fatty acid salts of betaxolol, a cardioselective beta-blocker, and ophthalmic compositions containing these salts are described. These new salts have an aqueous solubility significantly less than that of betaxolol hydrochloride. This relatively poor aqueous solubility enables the salts to be slowly released from a suitable ophthalmic vehicle when placed in the aqueous environment of the eye. The salts also exhibit a significantly lower incidence of ocular irritation, as compared to ophthalmic solutions containing betaxolol hydrochloride.
REFERENCES:
patent: 4136178 (1979-01-01), Lin et al.
patent: 4252984 (1981-02-01), Manoury et al.
patent: 4342783 (1982-08-01), Morselli et al.
patent: 4522829 (1985-06-01), Harting et al.
Gerson Steven H.
Han Wesley W.
Alcon Laboratories Inc.
Arno James A.
Brown Gregg C.
Evans J. E.
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