Fatty acid esters of 8-substituted 10-[4-(hydroxyalkyl)piperazin

Details Fatty acid esters of 8-substituted 10-[4-(hydroxyalkyl)piperazin Fatty acid esters of 8-substituted 10-[4-(hydroxyalkyl)piperazin

1974-07-19

1976-10-12

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424250, C07D40904

Patent

active

039857506

ABSTRACT:
Fatty acid esters of 8-substituted 10-[4-(hydroxyalkyl)piperazino]-10,11-dihydrodibenzo[b,f]thiepins and oxepins having the formula ##SPC1##
In which X is a sulfur or oxygen atom, R.sup.1 is a hydrogen, chloro, or trifluoromethyl radical, a lower alkyl radical having at most 5 carbon atoms, or a cycloalkyl radical having at least 3 and at most 8 carbon atoms, or an alkoxy or alkylthio radical the alkyl moiety of which has at most 4 carbon atoms, R.sup.2 is an alkyl radical having at least 5 and at most 17 carbon atoms, and n is 2, 3, or 4, and their salts with pharmaceutically acceptable inorganic and organic acids. The compounds have a high degree of neuroleptic activity and retain this activity for long periods after administration.
Related fatty acid esters of 8-substituted 10-[4-(hydroxyalkyl)-piperazino]dibenzo[b,f]thiepins and oxepins having the formula ##SPC2##
And fatty acid esters of 8-substituted 4-[4-(hydroxyalkyl)piperazino]thieno[2,3-b]-1-benzothiepins and oxepins having the formula ##SPC3##
In which formulae X, R.sup.1, R.sup.2 and n each have the foregoing significance, are also included herein.

REFERENCES:
patent: 3600391 (1971-08-01), Mastursi et al.
patent: 3600392 (1971-08-01), Zust et al.
patent: 3681354 (1972-08-01), Mastursi et al.
patent: 3830814 (1974-08-01), Jilek et al.
patent: 3875156 (1975-04-01), Blondel et al.
patent: 3875158 (1975-04-01), Blondel et al.

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