Fatty acid derivatives of aminoalkyl nicotinic acid esters and p

Details Fatty acid derivatives of aminoalkyl nicotinic acid esters and p Fatty acid derivatives of aminoalkyl nicotinic acid esters and p

1985-03-19

1986-10-28

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546318, 260404, A61K 31455, C07D21380

Patent

active

046199381

ABSTRACT:
Alkanolamine derivatives and platelet aggregation inhibitors containing the same as an active ingredient are disclosed. The alkanolamine derivatives are novel compounds which possess potent platelet aggregation inhibitory activities and effective in preventing diseases such as thrombosis. As typical compounds are mentioned N-5,8,11,14,17-eicosapentaenoyl-2-aminoethanol, N-nicotinoyl-2-aminoethyl-5,8,11,14,17-eicosapentaenoate, N-ethyl-N-5,8,11,14,17-eicosapentaenoyl-2-aminoethanol, N-butyl-N-5,8,11,14,17-eicosapentaenoyl-2-aminoethanol, N-5,8,11,14,17-3-aminopropylnicotinate, (N-ethyl-N-nicotinoyl-2-aminoethyl)-5,8,11,14,17-eicosapentaenoate and the like.

REFERENCES:
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patent: 4010193 (1977-03-01), Harsanyi et al.
Chemical Abstract 88:6739m of Japanese Patent 7797974.
Chemical Abstract 100:103136m of Seki, et al.
Chemical Abstracts, vol. 69, No. 5 (1968) 18550 p.
Patent Abstracts of Japan, vol. 5, No. 144, Sep., 11, 1981, p. (C-71) (816).
Patent Abstracts of Japan, vol. 8, No. 168, Aug. 3, 1984, p. (C-236) (1605) #1.
Patent Abstracts of Japan, vol. 8, No. 168, Aug. 3, 1984, p. (C-236) (1605) #2.

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