Fatty acid carriers for synthetic peptides

Drug – bio-affecting and body treating compositions – Lymphokine

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530406, 530345, A61K 3900

Patent

active

050193830

ABSTRACT:
A synthetic vaccine is contemplated comprising a peptide residue coupled to one or more alkyl or alkenyl groups of at least 12 carbon atoms or other lipophilic substance wherein said peptide residue contains a sequence of 6 amino acids corresponding to the sequence of such amino acids in a protein antigen or allergen where the greatest local average hydrophilicity of the antigen or allergen is found.

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patent: 4401658 (1983-08-01), Bouchaudon et al.
patent: 4415491 (1983-11-01), Vyas
Parsons, Peptide Hormones (1976) Chapter I pp. 2-7.
Proc. Natl. Acad. Sci. U.S.A., vol. 79, No. 2, Jan. 1982, pp. 579-582, Immunology; A. M. Prince et al.: "Hepatitis B Virus Vaccine: Identification of HBsAg/a and HBsAg/d but not HBsAg/y Subtype Antigenic Determinants on a Synthetic Immunogenic Peptide".
Proc. Natl. Acad. Sci. U.S.A., vol. 79, No. 14, Jul. 1982, pp. 4400-4404, Immunology; P. K. Bhatnagar et al: "Immune Response to Synthetic Peptide Analogues of Hepatitis B Surface Antigen Specific for the a Determinant".
Thomas P. Hopp. Immunogenicity of a Synthetic HBsAg Peptide: Enhancement by Conjugation to a Fatty Acid Carrier, Molecular Immunology, vol. 21, No. 1, pp. 13-16, 1984.
Stark et al., Immunology vol. 39, pp. 345-352, 1980 "Immunogenicity of Lipid Conjugated Antigens. I, The Influence of Chain Length and Degree of Conjugation on Indulation of Antibody in Mice".
Hopp, Thomas Proc. Nat'l Acad. Sci. vol. 78, No. 6, pp. 3824-3828 (Including Kenneth R. Woods) "Prediction of Protein . . . ".
Hopp, Thomas Dissertation Abstracts International Nov., 1977 Abstract 2155b.
Walter et al., Proc. Nat'l Acad. Sci. vol. 17, No. 9 Sep. 80, pp. 5197-5200 "Antibodies . . . Large Tumor Antigen".
Arnon, Ruth Pharmac. Ther. vol. 6, 1979, "Anti-Viral Activity Induced by Synthetic Peptides . . . ".
Walter et al., Proc. Natl. Acad Sci. U.S.A., vol. 77, No. 9 5197-5200, Sep. 1980.
Satcliffe et al., Nature, vol. 287, pp. 801-805, Oct. 30, 1980.

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