Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2007-06-12
2007-06-12
Dentz, Bernard (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S549000, C514S550000, C514S557000, C514S558000, C514S560000
Reexamination Certificate
active
10363963
ABSTRACT:
The present invention relates to fatty acid analogues of the general formula (I): R1-[xi-CH2]n—COOR2wherein R1is; a C1–C24alkene with one or more double bonds and/or with one or more triple bonds, and/or a C1–C24alkyne, and/or a C1–C24alkyl, or a C1–C24alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C1–C4alkoxy, C2–C4alkylthio, C1–C5acyloxy or C1–C4alkyl, and wherein R2 represents hydrogen or C1–C4alkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR2, and wherein Xiindependent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and with the proviso that at least one of the Xiis not CH2, and with the proviso that if R1 is an alkyne or alkene, then the carbon-carbon triple bond or double bond is positioned between the (ω-1) carbon and the (ω-2) carbon, or between the (ω-2) carbon and the (ω-3) carbon, or between the (ω-3) carbon and the (ω-4) carbon, which can be used for the treatment and/or prevention of proliferative skin disorders. More specifically the invention relates to the inhibition of proliferation and/or differentiation of keratinocytes.
REFERENCES:
patent: 6511670 (2003-01-01), Maignan et al.
patent: 6924309 (2005-08-01), Ferrante et al.
patent: 0273202 (1988-07-01), None
patent: 0742004 (1996-11-01), None
patent: WO 01/21575 (2001-03-01), None
patent: WO0168582 (2001-09-01), None
Berge Rolf
Kristiansen Karsten
Carella Byrne Bain eta
Dentz Bernard
Hand Francis C.
Thia Medica AS
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