Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2006-04-11
2006-04-11
Low, Christopher S. F. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S557000, C514S558000, C514S550000
Reexamination Certificate
active
07026356
ABSTRACT:
The present invention relates to novel fatty acid analogues of the general formula (I): CH3—[CH2]m—[xi—CH2]n—COOR, wherein n is an integer from 1 to 12, and wherein m is an integer from 0 to 23, and wherein i is an odd number which indicates the position relative to COOR, and wherein Xiindependent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and wherein R represents hydrogen or C1–C4alkyl, with the proviso that at least one of the Xiis not CH2, or a salt, prodrug or complex thereof, for the preparation of a pharmaceutical composition for the treatment and/or prevention of primary and/or secondary stenosis. Further the present invention relates to the use of said compounds for the prevention and/or treatment of a disease caused by procedural vascular trauma and/or pathological proliferation of smooth muscle cells, and/or an increased level of plasma homocysteine.
REFERENCES:
patent: 5827645 (1998-10-01), Sundrehagen
patent: 6046237 (2000-04-01), Berge et al.
patent: 6197789 (2001-03-01), Grainger et al.
patent: 6365628 (2002-04-01), Berge
patent: 6417232 (2002-07-01), Berge
patent: 0345038 (1993-11-01), None
patent: 2140688 (1984-12-01), None
patent: WO 97/03663 (1997-02-01), None
Lin et al. (J Biomed Sci 1999; 6:260-268).
Auge et al. (Artieroscler Thromb Vasc Biol, abstract, Dec. 1, 2002; 22(1):1990-5).
Auge et al. (Cir Res., abstract, Oct. 1996 79(4): 971-80).
“Heart Disease Coronary Artery Disease”, WebMDHealth, 2004.
“Heart Attack Prevention”, DrDonnica.com, 2000.
“Heart Disease: Heart Attack”, WebMDHealth, 2004.
“Stroke Treatment and Support”, Texas Heart Institute, 2004.
“Stroke”, Drug Digest, 2003.
Asiedu et al. (1996), “Long-term Effect of Tetradecylthioacetic Acid: A Study on Plasma Lipid Profile and Fatty Acid Composition and Oxidation in Different Rat Organs,”Biochimica et Biophysica Acta1300:86-96.
Dyroy et al. (1999), “The Influence of a Novel Antioxidant Fatty Acid on the Development of Stenosis After Balloon Injury,”Lipids34:S339.
Kwon Brian-Yong S.
Low Christopher S. F.
Reed IP Law Group
LandOfFree
Fatty acid analogues for the treatment of diseases caused by... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fatty acid analogues for the treatment of diseases caused by..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fatty acid analogues for the treatment of diseases caused by... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3609755