Fatty acid analogues for the treatment of cancer

Details Fatty acid analogues for the treatment of cancer Fatty acid analogues for the treatment of cancer

2008-05-27

2008-05-27

Henley, III, Raymond J. (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C514S550000, C514S552000, C514S558000, C514S560000

Reexamination Certificate

active

07378443

ABSTRACT:
A fatty acid analogue of the general formula: R1-[xi-CH2]n—COOR2, wherein R1is: a C2-C24alkene with one or more double bonds and/or with one or more triple bonds, and/or a C2-C24alkyne, and/or a C1-C24alkyl, or a C1-C24alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C1-C4alkoxy, C1-C4alkylthio, C2-C5acyloxy or C1-C4alkyl, and wherein R2 represents hydrogen or C1-C4alkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR2, and wherein Xiindependent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and with the proviso that at least one of the Xiis not CH2, and or a salt, prodrug or complex thereof is used in the treatment and/or prevention of primary and secondary metastatic neoplasms.

REFERENCES:
patent: 5750515 (1998-05-01), Shibata et al.
patent: 6046237 (2000-04-01), Berge et al.
patent: 6358915 (2002-03-01), Patierno et al.
patent: 7026356 (2006-04-01), Berge
patent: WO 97/03663 (1997-02-01), None
Cecil Texbook of Medicine, Goldman et al. (eds.), 21stEdition, vol. 1, published 2000 by W.B.Saunders Co. (PA), pp. 1060-1074.

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