Fatty acid analogs and prodrugs

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

554 35, 560 41, 560129, 560155, 562455, 562512, 564 78, 564201, 564202, C07C 54124, C07C 6902, C07C22906, C07C23331

Patent

active

056706502

ABSTRACT:
Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcohols, alcohol esters and nitriles thereof.
These compounds are useful as substrates for N-myristoyltransferase (NMT) and/or its acyl coenzyme, and as anti-viral and anti-fungal agents or pro-drugs of such agents. Illustrative of the disclosed compounds are fatty acid amino acid analogs of the structure ##STR1## in which X is the ethyl or t-butyl ester of an amino acid such as Gly, L-Ala, L-Ile, L-Phe, L-Trp, L-Thr or an amide such as NHCH.sub.2 C.sub.6 H.sub.5 or NH(CH.sub.2).sub.2 C.sub.6 H.sub.5.

REFERENCES:
patent: 5073571 (1991-12-01), Heuckeroth et al
patent: 5082967 (1992-01-01), Heuckeroth et al.
Towler et al., Rev. Biochem. 57, 69-99 (1988).
Bryant et al., Proc. Natl. Acad. Sci. USA 86, 8655-8659 (1989).
Bryant & Ratner, Proc. Natl. Acad. Sci. USA 87, 523-527 (1990).
Doering et al., Science 252, 1851-1854 (1991).
Bryant et al., Proc. Natl. Acad. Sci. USA 88, 2055-2059 (1991).
Devadas et al., J. Biol. Chem. 267, 7224-7239 (1992).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Fatty acid analogs and prodrugs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fatty acid analogs and prodrugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fatty acid analogs and prodrugs will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1939115

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.