Fatty acid analogs and prodrugs

Details Fatty acid analogs and prodrugs Fatty acid analogs and prodrugs

1998-10-20

1999-07-27

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514519, 514520, 514613, 514637, 548253, 5483381, 548483, 548491, 554 35, 554 42, 554103, 554113, 560 39, 560 40, A61K 3116, A61K 3121, C07C23506, C07D20904

Patent

active

059291109

ABSTRACT:
Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcohols, alcohol esters and nitriles thereof.
These compounds are useful as substrates for N-myristoyltransferase (NMT) and/or its acyl coenzyme, and as anti-viral and anti-fungal agents or pro-drugs of such agents. Illustrative of the disclosed compounds are fatty acid amino acid analogs of the structure ##STR1## in which X is the ethyl or t-butyl ester of an amino acid such as Gly, L-Ala, L-Ile, L-Phe, L-Trp, L-Thr or an amide such as NHCH.sub.2 C.sub.6 H.sub.5 or NH(CH.sub.2).sub.2 C.sub.6 H.sub.5.

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