Fatty acid analogs and prodrugs

Details Fatty acid analogs and prodrugs Fatty acid analogs and prodrugs

1995-03-24

1997-02-04

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483391, 560 41, 560170, C07D20920, C07D23364, C07C22906, C07C23301

Patent

active

055999476

ABSTRACT:
Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcohols, alcohol esters and nitriles thereof.
These compounds are useful as substrates for N-myristoyltransferase (NMT) and/or its acyl coenzyme, and as anti-viral and anti-fungal agents or pro-drugs of such agents. Illustrative of the disclosed compounds are fatty acid amino acid analogs of the structure ##STR1## in which X is the ethyl or t-butyl ester of an amino acid such as Gly, L--Ala, L--Ile, L--Phe, L--Trp, L--Thr or an amide such as NHCH.sub.2 C.sub.6 H.sub.5 or NH(CH.sub.2).sub.2 C.sub.6 H.sub.5,

REFERENCES:
patent: 5073571 (1991-12-01), Heuckeroth et al.
patent: 5082967 (1992-01-01), Heuckeroth et al.
Towler et al., Rev. Biochem. 57, 69-99 (1988).
Bryant et al., Proc. Natl. Acad. Sci. USA 86, 8655-8659 (1989).
Bryant & Ratner, Proc. Natl. Acad. Sci. USA 87, 523-527 (1991).
Doering et al., Science 252, 1851-1854 (1991).
Bryant et al., Proc. Natl. Acad. Sci. USA 88, 2055-2059, (1991).
Devadas et al., J. Biol. Chem. 267, 7224-7239 (1991).

Affiliated with

Also associated with

Rating

Fatty acid analogs and prodrugs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fatty acid analogs and prodrugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fatty acid analogs and prodrugs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-680037