Fatty acid analog enzyme substrates

Details Fatty acid analog enzyme substrates Fatty acid analog enzyme substrates

1993-07-15

1999-09-28

Burn, Brian M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 53126

Patent

active

059591455

ABSTRACT:
Novel oxy- and thio-substituted fatty acid analog substrates of myristoylating enzymes are provided which contain an oxygen or sulfur in place of a methylene group in a carbon position from 4 to 13 in the fatty acid chain of a C.sub.13 -C.sub.14 fatty acid or alkyl ester thereof.

REFERENCES:
patent: 4709012 (1987-11-01), Adams et al.
patent: 4740588 (1988-04-01), Adams et al.
Towler and Glaser, Biochemistry 25, 878-84 (1986).
Towler and Glaser, Proc. Natl. Acad. Sci.USA 83, 2812-2816 (1986).
Towler et al., Ibid. 84, 2708-2712 (1987).
Towler et al., J. Biol. Chem. 262, 1030-1036 (1987).
Towler et al., Ann. Rev. Biochem., 57, 69-99, (1988).
The Merck Index, Tenth Ed., 1983, p. ONR-96.
Pascal and Ziering, J. Lipid Res. 27, 221-224 (1986).
Heuckeroth et al., J. Biol. Chem. 263 (5), 2127-2133 (1988).
Aleynikov et al., Kolsk Branch of the USSR Academy of Sciences, May 3, 1961.
Belov et al., Zhokh, vol. 1, No. 4, D. I, Mendeleev Chemical Engrg. Institute in Moscow, Apr. 18, 1964.
Chem. Absts. 71: 90840 (1969).
Chem. Absts. 66: 28365 (1966).

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