Fat-binding polymers

Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Solid synthetic organic polymer

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S400000

Reexamination Certificate

active

07049345

ABSTRACT:
The present invention provides fat-binding polymers, which comprise dialkanolamine, dialkanolammonium, aminoalkylpolyol, and ammoniumalkylpolyol pendant groups for subjects in need of fat removal from the gastrointestinal tract, particularly subjects suffering from steatorrhea and/or experiencing side effects from lipase inhibitors. Patients being administered with lipase inhibitors are typically being treated for Type II Diabetes, streatorrhea, and hypertriglyceridemia. The fat binding polymers of this invention are also suitable for use with obese subjects.

REFERENCES:
patent: 3780171 (1973-12-01), Irmscher et al.
patent: 3923972 (1975-12-01), Fields et al.
patent: 4160826 (1979-07-01), Fischetti
patent: 4211765 (1980-07-01), Johnson et al.
patent: 4218443 (1980-08-01), Comai et al.
patent: 4265879 (1981-05-01), Fields et al.
patent: 4302450 (1981-11-01), Comai et al.
patent: 4432968 (1984-02-01), Page et al.
patent: 4598089 (1986-07-01), Hadvary et al.
patent: 4959179 (1990-09-01), Aronson et al.
patent: 5063210 (1991-11-01), Lange, III et al.
patent: 5089163 (1992-02-01), Aronson et al.
patent: 5137716 (1992-08-01), Weisenfeld
patent: 5200183 (1993-04-01), Tang et al.
patent: 5286481 (1994-02-01), Weisenfeld
patent: 5308766 (1994-05-01), Dennis et al.
patent: 5376674 (1994-12-01), Derungs et al.
patent: 5401498 (1995-03-01), Kesseler et al.
patent: 5427919 (1995-06-01), Dennis et al.
patent: 5453282 (1995-09-01), Kanauchi et al.
patent: 5453429 (1995-09-01), Bliem et al.
patent: 5474993 (1995-12-01), Rubin et al.
patent: 5484777 (1996-01-01), Lange, III et al.
patent: 5567597 (1996-10-01), Dennis et al.
patent: 5569452 (1996-10-01), Amidon et al.
patent: 5597810 (1997-01-01), Hoffman et al.
patent: 5607669 (1997-03-01), Mandeville, III et al.
patent: 5618530 (1997-04-01), Mandeville, III et al.
patent: 5624963 (1997-04-01), Mandeville, III et al.
patent: 5665348 (1997-09-01), Okayama et al.
patent: 5679717 (1997-10-01), Mandeville, III et al.
patent: 5693675 (1997-12-01), Mandeville, III et al.
patent: 5703188 (1997-12-01), Mandeville, III et al.
patent: 5750524 (1998-05-01), Mera et al.
patent: 5900233 (1999-05-01), Day
patent: 5900475 (1999-05-01), Mandeville, III et al.
patent: 6030953 (2000-02-01), Bailly et al.
patent: 6264937 (2001-07-01), Mandeville, III et al.
patent: 6299868 (2001-10-01), Jozefiak et al.
patent: 6358522 (2002-03-01), Hug et al.
patent: 6726906 (2004-04-01), Jozefiak et al.
patent: 0 050 347 (1982-04-01), None
patent: 0 129 748 (1985-01-01), None
patent: 0 381 262 (1990-08-01), None
patent: 0 050 346 (1994-04-01), None
patent: 2 081 400 (1971-12-01), None
patent: 04333694 (1992-11-01), None
patent: 06 321787 (1994-11-01), None
patent: WO 89/07455 (1989-08-01), None
patent: WO 01/05408 (2001-01-01), None
Gargouri, Y. et al., “Ajoene prevents fat digestion by human gastric lipasein vitro,” Biochimica et Biophysica Acta. 1006:137-139 (1989) .
Gargouri, Y et al., “Covalent inhibition of digestive lipases: anin vitrostudy,”Biochimica et Biophysica Acta. 1344:6-37 (1997) .
Karamac, M. and Amarowicz, R., “Inhibition of Pancreatic Lipase by Phenolic Acids, Examinationin vitro,” Verlag der Zeitschrift für Naturforschung:903-905 (1996) .
Marguet, F., et al., “Digestive lipases: inactivation by phosphonates,”Biochimica et Biophysica Acta. 1210:157-166 (1994) .
Mannesse, M.L.M., et al., “Phosphonate analogues of triacylglycerols are potent inhibitors of lipase,”Biochimica et Biophysica Acta. 1259:56-64 (1995) .
Martichonok, V. and Jones, J.B., “(Z) -Heptadec-8-enylboronic acid: a potential lipase inhibitor,”J. Chem. Soc. Perkin Trans. I:2927-2929 (1995) .
Vainio, P., et al., “Inhibition of Lipoprotein Lipase by Benzene Boronic Acid Effect of Apolipoprotein C-II,”Biochimica et Biophysica Acta. 711:386-390 (1982) .
Bagree, A., et al., “Modification of Epsilon-Amino Group of Lysine in Proteins by Acylation with Pyromellitic Dianhydride and O-Sulphobenzoic Anhydride,”FEBS Letters120(2):275-277 (1980) .
Stadler, P., et al., “Inhibition of microbial lipases with stereoisomeric triradylglycerol analog phosphonates,”Biochimica et Biophysica Acta. 1304:229-244 (1996) .
Kawaguchi, K. , et al., “Hesperidin as an Inhibitor of Lipases from Procine Pancreas andPseudomonas,” Biosci. Biotech. Biochem. 61(1):102-104 (1997) .
Bochenek, W.J. and Rodgers, J.B., “Effect of Polyol Detergents on Cholesterol and Triglyceride Absorption,”Biochimica et Biophysica Acta489:503-506 (1977) .
Comai, K. and Sullivan, A.C., “Antiobesity activity of pluronic L-101,”International Journal of Obesity4:33-42 (1980) .
Han, L-K, et al. , “Reduction in fat storage during chitin-chitosan treatment in mice fed a high-fat diet,”International Journal of Obesity23:174-179 (1999) .
Atkinson et al., “Combined Drug Treatment of Obesity,”Obesity Research, 3(S4):497S-500S (1995) .
Sjöström, et al., “Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients,”The Lancet, 352:167-172 (1998) .
CA Abstract, AN 127:156561, James et al. (1997) .
CA Abstract, AN 124:105377, Drent et al. (1995) .

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Fat-binding polymers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fat-binding polymers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fat-binding polymers will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3568203

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.